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The murine MHC class II super enhancer IA/IE-SE contains a functionally redundant CTCF-binding component and a novel element critical for maximal expression
In both humans and mice, CTCF-binding elements form a series of interacting loops across the MHC-II locus and CTCF is required for maximal MHC-II gene expression. In humans, a CTCF bound chromatin insulator termed XL9 and a super enhancer (SE) DR/DQ-SE situated in intergenic region between HLA-DRB1...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8062291/ https://ncbi.nlm.nih.gov/pubmed/33863790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001089 |
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