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The murine MHC class II super enhancer IA/IE-SE contains a functionally redundant CTCF-binding component and a novel element critical for maximal expression

In both humans and mice, CTCF-binding elements form a series of interacting loops across the MHC-II locus and CTCF is required for maximal MHC-II gene expression. In humans, a CTCF bound chromatin insulator termed XL9 and a super enhancer (SE) DR/DQ-SE situated in intergenic region between HLA-DRB1...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Majumder, Parimal, Lee, Joshua T., Barwick, Benjamin G., Patterson, Dillon G., Bally, Alexander P. R., Scharer, Christopher D., Boss, Jeremy M.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062291/
https://ncbi.nlm.nih.gov/pubmed/33863790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001089
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