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The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions
Knockdown of the insulator factor CCCTC binding factor (CTCF), which binds XL9, an intergenic element located between HLA-DRB1 and HLA-DQA1, was found to diminish expression of these genes. The mechanism involved interactions between CTCF and class II transactivator (CIITA), the master regulator of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292219/ https://ncbi.nlm.nih.gov/pubmed/18347100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071843 |
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