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Local Stabilization of Subunit–Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids

Development of antiviral molecules that bind virion is a strategy that remains in its infancy, and the details of their mechanisms are poorly understood. Here we investigate the behavior of DBT1, a dibenzothiazepine that specifically interacts with the capsid protein of hepatitis B virus (HBV). We f...

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Publicado en:ACS Chem Biol
Autores principales: Schlicksup, Christopher John, Laughlin, Patrick, Dunkelbarger, Steven, Wang, Joseph Che-Yen, Zlotnick, Adam
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062159/
https://ncbi.nlm.nih.gov/pubmed/32369333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00320
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