IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors

BACKGROUND: High serum interleukin (IL-6) levels may cause resistance to immunotherapy by modulation of myeloid cells in the tumor microenvironment. IL-6 signaling blockade is tested in cancer, but as this inflammatory cytokine has pleiotropic effects, this treatment is not always effective. METHODS...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Beyranvand Nejad, Elham, Labrie, Camilla, van Elsas, Marit J, Kleinovink, Jan Willem, Mittrücker, Hans-Willi, Franken, Kees L M C, Heink, Sylvia, Korn, Thomas, Arens, Ramon, van Hall, Thorbald, van der Burg, Sjoerd H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8061866/
https://ncbi.nlm.nih.gov/pubmed/33879600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002460
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