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IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors
BACKGROUND: High serum interleukin (IL-6) levels may cause resistance to immunotherapy by modulation of myeloid cells in the tumor microenvironment. IL-6 signaling blockade is tested in cancer, but as this inflammatory cytokine has pleiotropic effects, this treatment is not always effective. METHODS...
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| Udgivet i: | J Immunother Cancer |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMJ Publishing Group
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8061866/ https://ncbi.nlm.nih.gov/pubmed/33879600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002460 |
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