CD8(+) T cell priming in established chronic viral infection preferentially directs differentiation of memory-like cells for sustained immunity

CD8(+) T cell exhaustion impedes control of chronic viral infection; yet how new T cell responses are mounted during chronic infection is unclear. Unlike T cells primed at the onset of infection that rapidly differentiate into effectors and exhaust, we demonstrate that virus-specific CD8(+) T cells...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Immunity
Egile Nagusiak: Snell, Laura M., MacLeod, Bethany L., Law, Jaclyn C., Osokine, Ivan, Elsaesser, Heidi J., Hezaveh, Kebria, Dickson, Russell J., Gavin, Marc A., Guidos, Cynthia J., McGaha, Tracy L., Brooks, David G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060917/
https://ncbi.nlm.nih.gov/pubmed/30314757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.002
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