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CD8(+) T cell priming in established chronic viral infection preferentially directs differentiation of memory-like cells for sustained immunity
CD8(+) T cell exhaustion impedes control of chronic viral infection; yet how new T cell responses are mounted during chronic infection is unclear. Unlike T cells primed at the onset of infection that rapidly differentiate into effectors and exhaust, we demonstrate that virus-specific CD8(+) T cells...
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| Publicado no: | Immunity |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8060917/ https://ncbi.nlm.nih.gov/pubmed/30314757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.002 |
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