Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Using cells adhering to deformable micropillar arrays, we demonstrate that traction force and FAK localization as well as traction force and Y397-FAK phosphorylation are linearly...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhou, Dennis W., Fernández-Yagüe, Marc A., Holland, Elijah N., García, Andrés F., Castro, Nicolas S., O’Neill, Eric B., Eyckmans, Jeroen, Chen, Christopher S., Fu, Jianping, Schlaepfer, David D., García, Andrés J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060400/
https://ncbi.nlm.nih.gov/pubmed/33883558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22602-5
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