An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model

In order to identify more effective therapy for recalcitrant osteosarcoma, we evaluated the efficacy of an mTOR-VEGFR inhibitor combination on tumor growth in a unique osteosarcoma patient-derived orthotopic xenograft (PDOX) mouse model derived from the lung metastasis of an osteosarcoma patient who...

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Publicat a:Sci Rep
Autors principals: Oshiro, Hiromichi, Tome, Yasunori, Miyake, Kentaro, Higuchi, Takashi, Sugisawa, Norihiko, Kanaya, Fuminori, Nishida, Kotaro, Hoffman, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060249/
https://ncbi.nlm.nih.gov/pubmed/33883561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87553-9
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