Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD

BACKGROUND: Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, but how defective macrophage function contributes to exacerbations is not clear...

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Publicat a:Respir Res
Autors principals: Singh, R., Belchamber, K. B. R., Fenwick, P. S., Chana, K., Donaldson, G., Wedzicha, J. A., Barnes, P. J., Donnelly, L. E.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059282/
https://ncbi.nlm.nih.gov/pubmed/33879129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-021-01718-8
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