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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecule inhibitors with anti-inflammatory activity again...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bewley, Martin A., Belchamber, Kylie B. R., Chana, Kirandeep K., Budd, Richard C., Donaldson, Gavin, Wedzicha, Jadwiga A., Brightling, Christopher E., Kilty, Iain, Donnelly, Louise E., Barnes, Peter J., Singh, Dave, Whyte, Moira K. B., Dockrell, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040258/
https://ncbi.nlm.nih.gov/pubmed/27680884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163139
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