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Thermodynamics and kinetics of phase separation of protein-RNA mixtures by a minimal model

Intracellular liquid-liquid phase separation enables the formation of biomolecular condensates, such as ribonucleoprotein granules, which play a crucial role in the spatiotemporal organization of biomolecules (e.g., proteins and RNAs). Here, we introduce a patchy-particle polymer model to investigat...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Joseph, Jerelle A., Espinosa, Jorge R., Sanchez-Burgos, Ignacio, Garaizar, Adiran, Frenkel, Daan, Collepardo-Guevara, Rosana
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059209/
https://ncbi.nlm.nih.gov/pubmed/33571491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.01.031
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