Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma

Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition of cystine-glutamate antiporter system X(C)(-) because of the impaired uptake of cystine. However, the outcome following the accumulation of endogenous glutamate in lung adenocarcinoma (L...

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Publicat a:Theranostics
Autors principals: Zhang, Xiao, Yu, Keke, Ma, Lifang, Qian, Zijun, Tian, Xiaoting, Miao, Yayou, Niu, Yongjie, Xu, Xin, Guo, Susu, Yang, Yueyue, Wang, Zhixian, Xue, Xiangfei, Gu, Chuanjia, Fang, Wentao, Sun, Jiayuan, Yu, Yongchun, Wang, Jiayi
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058707/
https://ncbi.nlm.nih.gov/pubmed/33897873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55482
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