Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

OBJECTIVES: Tumour-positive resection margins are a major problem during oral cancer surgery. gGlu-HMRG is a tracer that becomes fluorescent upon activation by gamma-glutamyltranspeptidase (GGT). This study aims to investigate the combination of gGlu-HMRG and a clinical fluorescence imaging system f...

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Veröffentlicht in:Oral Oncol
Hauptverfasser: Slooter, Maxime D., Handgraaf, Henricus J.M., Boonstra, Martin C., van der Velden, Lily-Ann, Bhairosingh, Shadhvi S., Que, Ivo, de Haan, Lorraine M., Keereweer, Stijn, van Driel, Pieter B.A.A., Chan, Alan, Kobayashi, Hisataka, Vahrmeijer, Alexander L., Löwik, Clemens W.G.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058622/
https://ncbi.nlm.nih.gov/pubmed/29496035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2017.12.006
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