EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Photodynamic therapy (PDT) induces cell death through local light activation of a photosensitizer (PS) and has been used to treat head and neck cancers. Yet, common PS lack tumor specificity, which leads to collateral damage to normal tissues. Targeted delivery of PS via antibodies has pre-clinicall...

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Udgivet i:J Control Release
Main Authors: van Driel, Pieter B.A.A., Boonstra, Martin C., Slooter, Maxime D., Heukers, Raimond, Stammes, Marieke A., Snoeks, Thomas J.A., de Bruijn, Henriette S., van Diest, Paul J., Vahrmeijer, Alexander L., van Bergen en Henegouwen, Paul M.P., van de Velde, Cornelis J.H., Löwik, Clemens W.G.M., Robinson, Dominic J., Oliveira, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116242/
https://ncbi.nlm.nih.gov/pubmed/26988602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.03.014
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