Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Targeted photodynamic therapy (PDT) has the potential to selectively damage tumor tissue and to increase tumor vessel permeability. Here we characterize the tissue biodistribution of two EGFR-targeted nanobody-photosensitizer conjugates (NB-PS), the monovalent 7D12-PS and the biparatopic 7D12-9G8-PS...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: de Bruijn, Henriette S., Mashayekhi, Vida, Schreurs, Tom J.L., van Driel, Pieter B.A.A., Strijkers, Gustav J., van Diest, Paul J., Lowik, Clemens W.G.M., Seynhaeve, Ann L.B., ten Hagen, Timo L.M., Prompers, Jeanine J., van Bergen en Henegouwen, Paul M.P., Robinson, Dominic J., Oliveira, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019176/
https://ncbi.nlm.nih.gov/pubmed/32089747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.37949
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