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Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Targeted photodynamic therapy (PDT) has the potential to selectively damage tumor tissue and to increase tumor vessel permeability. Here we characterize the tissue biodistribution of two EGFR-targeted nanobody-photosensitizer conjugates (NB-PS), the monovalent 7D12-PS and the biparatopic 7D12-9G8-PS...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: de Bruijn, Henriette S., Mashayekhi, Vida, Schreurs, Tom J.L., van Driel, Pieter B.A.A., Strijkers, Gustav J., van Diest, Paul J., Lowik, Clemens W.G.M., Seynhaeve, Ann L.B., ten Hagen, Timo L.M., Prompers, Jeanine J., van Bergen en Henegouwen, Paul M.P., Robinson, Dominic J., Oliveira, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019176/
https://ncbi.nlm.nih.gov/pubmed/32089747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.37949
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