The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca(2+) Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

NMDA receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute cent...

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Опубликовано в: :Mol Pharmacol
Главные авторы: Perszyk, Riley E., Zheng, Zhaoshi, Banke, Tue G., Zhang, Jing, Xie, Lingling, McDaniel, Miranda J., Katzman, Brooke M., Pelly, Stephen C., Yuan, Hongjie, Liotta, Dennis C., Traynelis, Stephen F.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058507/
https://ncbi.nlm.nih.gov/pubmed/33688039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000218
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