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TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma

Glaucoma is the leading cause of irreversible vision loss, affecting more than 70 million individuals worldwide. Circulatory disturbances of aqueous humor (AH) have long been central pathological contributors to glaucomatous lesions. Thus, targeting the AH outflow is a promising approach to treat gl...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Wan, Peixing, Long, Erping, Li, Zhidong, Zhu, Yingting, Su, Wenru, Zhuo, Yehong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058441/
https://ncbi.nlm.nih.gov/pubmed/33388417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.030
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