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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

Oligonucleotide therapeutics hold promise for the treatment of muscle- and heart-related diseases. However, oligonucleotide delivery across the continuous endothelium of muscle tissue is challenging. Here, we demonstrate that docosanoic acid (DCA) conjugation of small interfering RNAs (siRNAs) enabl...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Biscans, Annabelle, Caiazzi, Jillian, McHugh, Nicholas, Hariharan, Vignesh, Muhuri, Manish, Khvorova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058398/
https://ncbi.nlm.nih.gov/pubmed/33348054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.023
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