Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma

BACKGROUND: While programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) antagonists have improved the prognosis for many patients with melanoma, around 60% fail therapy. PVSRIPO is a non-neurovirulent rhinovirus:poliovirus chimera that facilitates an antitumor immune response...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Beasley, Georgia M, Nair, Smita K, Farrow, Norma E, Landa, Karenia, Selim, Maria Angelica, Wiggs, Carol Ann, Jung, Sin-Ho, Bigner, Darell D, True Kelly, Andrea, Gromeier, Matthias, Salama, April KS
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Oncolytic and Local Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057552/
https://ncbi.nlm.nih.gov/pubmed/33875611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002203
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