Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

Intratumoral inoculation of viruses with tumor-selective cytotoxicity may induce cancer cell death and, thereby, shrink neoplastic lesions. It is unlikely, however, that viral tumor cell killing alone could produce meaningful, durable clinical responses, as clinically suitable ‘oncolytic’ viruses ar...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Holl, Eda K., Brown, Michael C., Boczkowski, David, McNamara, Megan A., George, Daniel J., Bigner, Darell D., Gromeier, Matthias, Nair, Smita K.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346754/
https://ncbi.nlm.nih.gov/pubmed/27806313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12975
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