Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

Intratumoral inoculation of viruses with tumor-selective cytotoxicity may induce cancer cell death and, thereby, shrink neoplastic lesions. It is unlikely, however, that viral tumor cell killing alone could produce meaningful, durable clinical responses, as clinically suitable ‘oncolytic’ viruses ar...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Holl, Eda K., Brown, Michael C., Boczkowski, David, McNamara, Megan A., George, Daniel J., Bigner, Darell D., Gromeier, Matthias, Nair, Smita K.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346754/
https://ncbi.nlm.nih.gov/pubmed/27806313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12975
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