PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the blood system in response to inflammatory cues; however, excessive proliferation in response to chronic inflammation can lead to either HSC attrition or expansion. The mechanism(s) that limit HSC proliferation and...

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Publicado no:J Exp Med
Main Authors: Chavez, James S., Rabe, Jennifer L., Loeffler, Dirk, Higa, Kelly C., Hernandez, Giovanny, Mills, Taylor S., Ahmed, Nouraiz, Gessner, Rachel L., Ke, Zhonghe, Idler, Beau M., Niño, Katia E., Kim, Hyunmin, Myers, Jason R., Stevens, Brett M., Davizon-Castillo, Pavel, Jordan, Craig T., Nakajima, Hideaki, Ashton, John, Welner, Robert S., Schroeder, Timm, DeGregori, James, Pietras, Eric M.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056754/
https://ncbi.nlm.nih.gov/pubmed/33857288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201169
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