Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity

Lymphatic endothelial cells (LECs) present peripheral tissue antigens to induce T cell tolerance. In addition, LECs are the main source of sphingosine-1-phosphate (S1P), promoting naive T cell survival and effector T cell exit from lymph nodes (LNs). Autophagy is a physiological process essential fo...

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Publicat a:J Exp Med
Autors principals: Harlé, Guillaume, Kowalski, Camille, Dubrot, Juan, Brighouse, Dale, Clavel, Gaëlle, Pick, Robert, Bessis, Natacha, Niven, Jennifer, Scheiermann, Christoph, Gannagé, Monique, Hugues, Stéphanie
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056750/
https://ncbi.nlm.nih.gov/pubmed/33861848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201776
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