Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9

Removal of empty capsids from adeno-associated virus (AAV) manufacturing lots remains a critical step in the downstream processing of AAV clinical-grade batches. Because of similar physico-chemical characteristics, the AAV capsid populations totally lacking or containing partial viral DNA are diffic...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Joshi, Pranav R.H., Bernier, Alice, Moço, Pablo D., Schrag, Joseph, Chahal, Parminder S., Kamen, Amine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056178/
https://ncbi.nlm.nih.gov/pubmed/33898632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.016
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