Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System

Despite numerous advancements in production protocols, manufacturing AAV to meet exceptionally high demand (10(16)–10(17) viral genomes [VGs]) in late clinical stages and for eventual systemic delivery poses significant challenges. Here, we report an efficient, simple, scalable, robust AAV5 producti...

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Bibliografiset tiedot
Julkaisussa:Mol Ther Methods Clin Dev
Päätekijät: Joshi, Pranav R.H., Cervera, Laura, Ahmed, Ibrahim, Kondratov, Oleksandr, Zolotukhin, Sergei, Schrag, Joseph, Chahal, Parminder S., Kamen, Amine A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404649/
https://ncbi.nlm.nih.gov/pubmed/30886878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.02.003
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