A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) and other tumor types. LH2 hydroxylates lysine (Lys)...

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Vydáno v:Commun Biol
Hlavní autoři: Guo, Hou-Fu, Bota-Rabassedas, Neus, Terajima, Masahiko, Leticia Rodriguez, B., Gibbons, Don L., Chen, Yulong, Banerjee, Priyam, Tsai, Chi-Lin, Tan, Xiaochao, Liu, Xin, Yu, Jiang, Tokmina-Roszyk, Michal, Stawikowska, Roma, Fields, Gregg B., Miller, Mitchell D., Wang, Xiaoyan, Lee, Juhoon, Dalby, Kevin N., Creighton, Chad J., Phillips, George N., Tainer, John A., Yamauchi, Mitsuo, Kurie, Jonathan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055892/
https://ncbi.nlm.nih.gov/pubmed/33875777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01982-w
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