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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding
Collagen lysyl hydroxylases (LH1-3) are Fe(2+)- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5802723/ https://ncbi.nlm.nih.gov/pubmed/29410444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02859-z |
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