Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding

Collagen lysyl hydroxylases (LH1-3) are Fe(2+)- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require...

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Pubblicato in:Nat Commun
Autori principali: Guo, Hou-Fu, Tsai, Chi-Lin, Terajima, Masahiko, Tan, Xiaochao, Banerjee, Priyam, Miller, Mitchell D., Liu, Xin, Yu, Jiang, Byemerwa, Jovita, Alvarado, Sarah, Kaoud, Tamer S., Dalby, Kevin N., Bota-Rabassedas, Neus, Chen, Yulong, Yamauchi, Mitsuo, Tainer, John A., Phillips, George N., Kurie, Jonathan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802723/
https://ncbi.nlm.nih.gov/pubmed/29410444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02859-z
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