Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

Evaluating the structure-function relationship of viral envelope (Env) evolution and the development of broadly cross-neutralizing antibodies (bnAbs) in natural infection can inform rational immunogen design. In the present study, we examined the magnitude and specificity of autologous neutralizing...

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Publicado en:PLoS Pathog
Main Authors: Kumar, Rajesh, Deshpande, Suprit, Sewall, Leigh M., Ozorowski, Gabriel, Cottrell, Christopher A., Lee, Wen-Hsin, Holden, Lauren G., Richey, Sara T., Chandrawacar, Antra Singh, Dhiman, Kanika, Ashish, Kumar, Vivek, Ahmed, Shubbir, Hingankar, Nitin, Kumar, Naresh, Murugavel, Kailapuri G., Srikrishnan, Aylur K., Sok, Devin, Ward, Andrew B., Bhattacharya, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055034/
https://ncbi.nlm.nih.gov/pubmed/33826683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008977
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