Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy

HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of integration sites (IS), we compared about 15,000...

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Vydáno v:PLoS Pathog
Hlavní autoři: Coffin, John M., Bale, Michael J., Wells, Daria, Guo, Shuang, Luke, Brian, Zerbato, Jennifer M., Sobolewski, Michele D., Sia, Twan, Shao, Wei, Wu, Xiaolin, Maldarelli, Frank, Kearney, Mary F., Mellors, John W., Hughes, Stephen H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055010/
https://ncbi.nlm.nih.gov/pubmed/33826675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009141
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