An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses

Abstract Background All retroviruses, including human immunodeficiency virus (HIV), must integrate a DNA copy of their genomes into the genome of the infected host cell to replicate. Although integrated retroviral DNA, known as a provirus, can be found at many sites in the host genome, integration i...

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Autori principali: Daria W. Wells, Shuang Guo, Wei Shao, Michael J. Bale, John M. Coffin, Stephen H. Hughes, Xiaolin Wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-03-01
Serie:BMC Genomics
Soggetti:
Retrovirus
Patient samples
HIV
Integration
PCR mispriming
PCR recombination
Accesso online:http://link.springer.com/article/10.1186/s12864-020-6647-4
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