Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection

BACKGROUND: Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger the recruitment of innate immune effectors, including NK cells. Activated NK cells contribute to microvascular inflammation leading to chron...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Koenig, Alice, Mezaache, Sarah, Callemeyn, Jasper, Barba, Thomas, Mathias, Virginie, Sicard, Antoine, Charreau, Béatrice, Rabeyrin, Maud, Dijoud, Frédérique, Picard, Cécile, Meas-Yedid, Vannary, Olivo-Marin, Jean-Christophe, Morelon, Emmanuel, Naesens, Maarten, Dubois, Valérie, Thaunat, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2021
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054908/
https://ncbi.nlm.nih.gov/pubmed/33239394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020040433
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