Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection

BACKGROUND: Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger the recruitment of innate immune effectors, including NK cells. Activated NK cells contribute to microvascular inflammation leading to chron...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Koenig, Alice, Mezaache, Sarah, Callemeyn, Jasper, Barba, Thomas, Mathias, Virginie, Sicard, Antoine, Charreau, Béatrice, Rabeyrin, Maud, Dijoud, Frédérique, Picard, Cécile, Meas-Yedid, Vannary, Olivo-Marin, Jean-Christophe, Morelon, Emmanuel, Naesens, Maarten, Dubois, Valérie, Thaunat, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2021
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054908/
https://ncbi.nlm.nih.gov/pubmed/33239394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020040433
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