Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes

Clinical outcome in antibody-mediated rejection (AMR) shows high inter-individual heterogeneity. Sialylation status of the Fc fragment of IgGs is variable, which could modulate their ability to bind to C1q and/or Fc receptors. In this translational study, we evaluated whether DSA sialylation influen...

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Gepubliceerd in:Front Immunol
Hoofdauteurs: Barba, Thomas, Harb, Jean, Ducreux, Stéphanie, Koenig, Alice, Mathias, Virginie, Rabeyrin, Maud, Pouliquen, Eric, Sicard, Antoine, Chartoire, Dimitri, Dugast, Emilie, Defrance, Thierry, Morelon, Emmanuel, Brouard, Sophie, Dubois, Valérie, Thaunat, Olivier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435580/
https://ncbi.nlm.nih.gov/pubmed/30949173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00513
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