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Type I interferon in the pathogenesis of systemic lupus erythematosus

Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as rare monogenic influences on type I IFN have been demonstrated, supporting...

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Detalhes bibliográficos
Publicado no:Curr Opin Immunol
Main Authors: Postal, Mariana, Vivaldo, Jessica F., Fernandez-Ruiz, Ruth, Paredes, Jacqueline L., Appenzeller, Simone, Niewold, Timothy B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054829/
https://ncbi.nlm.nih.gov/pubmed/33246136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2020.10.014
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