MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma

The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is incompletely...

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發表在:Sci Transl Med
Main Authors: Yohe, Marielle E., Gryder, Berkley E., Shern, Jack F., Song, Young K., Chou, Hsien-Chao, Sindiri, Sivasish, Mendoza, Arnulfo, Patidar, Rajesh, Zhang, Xiaohu, Guha, Rajarashi, Butcher, Donna, Isanogle, Kristine A., Robinson, Christina M., Luo, Xiaoling, Chen, Jin-Qiu, Walton, Ashley, Awasthi, Parirokh, Edmondson, Elijah F., Difilippantonio, Simone, Wei, Jun S., Zhao, Keji, Ferrer, Marc, Thomas, Craig J., Khan, Javed
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054766/
https://ncbi.nlm.nih.gov/pubmed/29973406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan4470
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