Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

BACKGROUND: Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset. We have shown previously that monocytes from Huntington’s...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: O’Regan, Grace C., Farag, Sahar H., Casey, Caroline S., Wood-Kaczmar, Alison, Pocock, Jennifer M., Tabrizi, Sarah J., Andre, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054367/
https://ncbi.nlm.nih.gov/pubmed/33874957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02147-6
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