Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins

Guanylate-binding proteins (GBPs) form a family of dynamin-related large GTPases which mediate important innate immune functions. They were proposed to form oligomers upon GTP binding/hydrolysis, but the molecular mechanisms remain elusive. Here, we present crystal structures of C-terminally truncat...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cui, Wen, Braun, Elisabeth, Wang, Wei, Tang, Jinhong, Zheng, Yanyan, Slater, Benjamin, Li, Na, Chen, Cheng, Liu, Qingxiang, Wang, Bin, Li, Xiu, Duan, Yinkai, Xiao, Yunjie, Ti, Ruijiao, Hotter, Dominik, Ji, Xiaoyun, Zhang, Lei, Cui, Jun, Xiong, Yong, Sauter, Daniel, Wang, Zefang, Kirchhoff, Frank, Yang, Haitao
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054025/
https://ncbi.nlm.nih.gov/pubmed/33876762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022269118
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