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Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut

The bacterium Clostridium perfringens causes severe, sometimes lethal gastrointestinal disorders in humans, including enteritis and enterotoxemia. Type F strains produce an enterotoxin (CpE) that causes the third most common foodborne illness in the United States. CpE induces gut breakdown by disrup...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Vecchio, Alex J., Rathnayake, Sewwandi S., Stroud, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053971/
https://ncbi.nlm.nih.gov/pubmed/33876770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024651118
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