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Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut

The bacterium Clostridium perfringens causes severe, sometimes lethal gastrointestinal disorders in humans, including enteritis and enterotoxemia. Type F strains produce an enterotoxin (CpE) that causes the third most common foodborne illness in the United States. CpE induces gut breakdown by disrup...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Vecchio, Alex J., Rathnayake, Sewwandi S., Stroud, Robert M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053971/
https://ncbi.nlm.nih.gov/pubmed/33876770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024651118
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