Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands: Evidence for Direct Involvement of Claudins in Tight Junction Barrier

Claudins, comprising a multigene family, constitute tight junction (TJ) strands. Clostridium perfringens enterotoxin (CPE), a single ∼35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half. We examined the effects of the COOH-terminal hal...

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Autors principals: Sonoda, Noriyuki, Furuse, Mikio, Sasaki, Hiroyuki, Yonemura, Shigenobu, Katahira, Jun, Horiguchi, Yasuhiko, Tsukita, Shoichiro
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1999
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2164970/
https://ncbi.nlm.nih.gov/pubmed/10508866
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