Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma

PURPOSE: Isocitrate dehydrogenase 1 (IDH1) mutations are the most common genetic abnormalities in low-grade gliomas and secondary glioblastomas. Glioma patients with these mutations had better clinical outcomes. However, the effect of IDH1 mutation on drug sensitivity is still under debate. MATERIAL...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res Treat
Asıl Yazarlar: Lin, Lin, Cai, Jinquan, Tan, Zixiao, Meng, Xiangqi, Li, Ruiyan, Li, Yang, Jiang, Chuanlu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Korean Cancer Association 2021
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053882/
https://ncbi.nlm.nih.gov/pubmed/33070553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2020.506
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