Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma

Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett’s esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using no...

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Publicado en:Carcinogenesis
Autores principales: Dighe, Shruti G, Chen, Jianhong, Yan, Li, He, Qianchuan, Gharahkhani, Puya, Onstad, Lynn, Levine, David M, Palles, Claire, Ye, Weimin, Gammon, Marilie D, Iyer, Prasad G, Anderson, Lesley A, Liu, Geoffrey, Wu, Anna H, Dai, James Y, Chow, Wong-Ho, Risch, Harvey A, Lagergren, Jesper, Shaheen, Nicholas J, Bernstein, Leslie, Corley, Douglas A, Prenen, Hans, deCaestecker, John, MacDonald, David, Moayyedi, Paul, Barr, Hugh, Love, Sharon B, Chegwidden, Laura, Attwood, Stephen, Watson, Peter, Harrison, Rebecca, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismüller, Josef, Gockel, Ines, Vashist, Yogesh, Nöthen, Markus M, Izbicki, Jakob R, Manner, Hendrik, Neuhaus, Horst, Rösch, Thomas, Böhmer, Anne C, Hölscher, Arnulf H, Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Ambrosone, Christine B, Moysich, Kirsten B, MacGregor, Stuart, Tomlinson, Ian, Whiteman, David C, Jankowski, Janusz, Schumacher, Johannes, Vaughan, Thomas L, Madeleine, Margaret M, Hardie, Laura J, Buas, Matthew F
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Cancer Biomarkers and Molecular Epidemiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052954/
https://ncbi.nlm.nih.gov/pubmed/33300568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa132
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