Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1

BACKGROUND: Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alternative s...

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Detalles Bibliográficos
Publicado en:Cancer Metab
Autores principales: Choksi, Arpankumar, Parulekar, Apoorva, Pant, Richa, Shah, Vibhuti Kumar, Nimma, Ramakrishna, Firmal, Priyanka, Singh, Smriti, Kundu, Gopal C., Shukla, Sanjeev, Chattopadhyay, Samit
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052847/
https://ncbi.nlm.nih.gov/pubmed/33863392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00252-x
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