SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation

Acetylation status of DNA end joining protein Ku70 dictates its function in DNA repair and Bax-mediated apoptosis. Despite the knowledge of HDACs and HATs that are reported to modulate the acetylation dynamics of Ku70, very little is known about proteins that critically coordinate these key modifica...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Chaudhary, N, Nakka, K K, Chavali, P L, Bhat, J, Chatterjee, S, Chattopadhyay, S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237237/
https://ncbi.nlm.nih.gov/pubmed/25299772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.397
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