Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1

BACKGROUND: Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alternative s...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Choksi, Arpankumar, Parulekar, Apoorva, Pant, Richa, Shah, Vibhuti Kumar, Nimma, Ramakrishna, Firmal, Priyanka, Singh, Smriti, Kundu, Gopal C., Shukla, Sanjeev, Chattopadhyay, Samit
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052847/
https://ncbi.nlm.nih.gov/pubmed/33863392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00252-x
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