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Avoid the Trap: Targeting PARP1 Beyond Human Malignancy
PARP1 is a Poly-ADP-ribose Polymerase (PARP) enzyme that plays a critical role in regulating DNA damage response. The main enzymatic function of PARP1 is to catalyze a protein posttranslational modification known as Poly-ADP-Ribosylation (PARylation). Human cancers with homologous recombination defi...
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| Udgivet i: | Cell Chem Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052287/ https://ncbi.nlm.nih.gov/pubmed/33657415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.02.004 |
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