Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Wang, Shuai, Han, Lei, Han, Jungsoo, Li, Peng, Ding, Qing, Zhang, Qing-Jun, Liu, Zhi-Ping, Chen, Chuo, Yu, Yonghao
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864272/
https://ncbi.nlm.nih.gov/pubmed/31659317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0379-2
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