Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function

Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide adenine dinucleotide phosphate (NADPH), we examined how PPP bl...

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Publicat a:Cell Rep
Autors principals: Daneshmandi, Saeed, Cassel, Teresa, Lin, Penghui, Higashi, Richard M., Wulf, Gerburg M., Boussiotis, Vassiliki A., Fan, Teresa W.-M., Seth, Pankaj
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051863/
https://ncbi.nlm.nih.gov/pubmed/33691103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108831
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