Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients. We have recently reported that programmed cell death protein-1 (PD-1) ligand (PD-L1) expression is regulated by lactate present at high levels in the tumor microenvironment (TME)....

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Bibliografische gegevens
Hoofdauteurs: Saeed Daneshmandi, Barbara Wegiel, Pankaj Seth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2019-03-01
Reeks:Cancers
Onderwerpen:
LDH-A
lactate
PD-1
PD-L1
melanoma
Online toegang:https://www.mdpi.com/2072-6694/11/4/450
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