Enantioselective Bifunctional Ammonium Salt‐Catalyzed Syntheses of 3‐CF(3)S‐, 3‐RS‐, and 3‐F‐Substituted Isoindolinones

We herein report the ammonium salt‐catalyzed synthesis of chiral 3,3‐disubstituted isoindolinones bearing a heteroatom functionality in the 3‐position. A broad variety of differently substituted CF(3)S‐ and RS‐derivatives were obtained with often high enantioselectivities when using Maruoka's b...

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Publicado en:Adv Synth Catal
Main Authors: Eitzinger, Andreas, Otevrel, Jan, Haider, Victoria, Macchia, Antonio, Massa, Antonio, Faust, Kirill, Spingler, Bernhard, Berkessel, Albrecht, Waser, Mario
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050839/
https://ncbi.nlm.nih.gov/pubmed/33897314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.202100029
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